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Funding This work was financially supported by grants from the National Key R&D Program of China (2023YFA1801200), the National Natural Science Foundation of China (U23A20475, 32288101, 82300574, 31871436), CAMS Innovation Fund for Medical Science (2019-I2M-5-066), and Shanghai Municipal Science and Technology Major Project (2023SHZDZX02, 2017SHZDZX01)

Some early studies in animals have shown a potential risk to foetal development, which is why current advice is to avoid use in pregnancy and stop treatment well in advance of trying to conceive

Accessed July 1, 2026

The slow intravenous infusion protocols used in clinical trials minimized these effects, suggesting that rapid bolus administration (which is essentially what subcutaneous injection creates) may increase the likelihood of transient side effects

Increasing evidences show that oxidative stress contributes significantly to the development of gastric cancer, either through initiation, promotion, and progression of cancer cells or causing cell death

Major tripeptide widely distributed in both plants and animals